Lamellar ichthyosis, the skin condition that causes constant skin shedding

Jagannath, an Indian boy dubbed, "snake skin" because he has the rare skin condition called lamellar ichthyosis
EJ
Emeh Joy

In January 2020, 7News.com published a report about an Indian boy who was dubbed "human snake" because of his rare skin condition.

This skin condition diagnosed to be lamellar ichthyosis causes his skin to grow rapidly, dry out and shed. This young boy, Jagannath, who is from Ganjam district of eastern India experiences shedding of his skin every month.

His Lamellar ichthyosis condition was so severe that he sheds his skin every four to six weeks. That is surprising and extreme, right?

But, that is not even all to Jagannath's predicament. This young lad's skin gets so tight that most times, he is unable to walk properly and would need a stick to help him stretch out his limbs.

The young Indian boy was always forced to take his bath every hour and apply moisturiser at least every three hours, all in the bid to relieve the symptoms.

Even though they didn't have the funds for additional treatment, Jagannath'a parents has to make sure he takes his bath every hour and apply moisturizers regularly to help manage his skin condition

This is a pathetic story, but sadly, there is no permanent cure for lamellar ichthyosis which Jagannath suffers from. Also, his father, who works as a field labourer had no sufficient fund to take his son for some treatment to help manage the condition.

Have you heard about lamellar ichthyosis? Do you know someone with this rare skin condition?

What is lamellar ichthyosis?

Lamellar ichthyosis is a rare skin condition which is present at birth and continues throughout a lifetime. It bears other names like 'collodian baby', ichthyosis congenital and autosomal recessive congenital ichthyosis.

Its names are related to its symptoms and the fact that it is genetic and an autosomal recessive disorder. A baby with this condition is born encased in a collodion membrane which sheds within 10 to 14 days.

After shedding of the membrane, skin with generalised scaling and variable redness would be revealed. Typically, the scaling makes the skin look like that of a fish, but in some cases, it would appear fine or smooth (platelike).

But, what causes lamellar ichthyosis?

What causes lamellar ichthyosis disorder?

Mutations in the TGM1 gene cause about 90 per cent of cases of lamellar ichthyosis. The TGM1 gene is the gene that provides instruction for making the enzyme, transglutaminase 1.

Transglutaminase is found in cells of the epidermis. It is involved in the formation of the cell envelope (a structure surrounding skin cells and helping to form a protective barrier between the body and the external environment).

Top facts about lamellar ichthyosis: It is a rare skin condition with no cure. It is genetic and not contagious

There are also few cases whereby lamellar ichthyosis would be caused by mutation of some other genes asides the TGM1 gene.

It is generally inherited as an autosomal recessive disorder which means that for a baby to develop this disease, both parents must pass one abnormal copy of the disease gene to the baby.

Symptoms of lamellar ichthyosis

Babies with lamellar ichthyosis are usually born with a clear, waxy and shiny skin layer called 'collodion membrane'. Hence, these babies are called 'collodian babies'.

This membrane sheds later after about two weeks; thus, revealing the red scaly skin underneath which looks like fish skin. Signs and symptoms also vary in children. A baby with lamellar ichthyosis could experience the following:

  • Loss of fluid (dehydration)
  • Difficulty in feeding
  • Unstable body temperature
  • Breathing problems
  • Skin or body infections

Older children like Jagannath (the young Indian boy), with this skin condition, lamellar ichthyosis may experience these symptoms:

  • Large scales covering most parts of the body
  • Hair loss
  • The decreased ability or inability to sweat which causes sensitivity to heat
  • Thickened skin on the soles of the feet and palms of the hands
  • Abnormal finger and toenails

Is lamellar ichthyosis life-threatening?

Lamellar ichthyosis condition is not life-threatening. However, it is a condition that causes severe disfiguring of the human body or looks.

For the affected patients, lamellar ichthyosis can cause considerable psychological stress.

Is there a cure or treatment for lamellar ichthyosis?

It is unfortunate that currently, there is no permanent cure for lamellar ichthyosis. However, there are management procedures that help to support affected children based on the signs and symptoms each person experiences.

For infants, they are mostly kept in a moist environment, like an isolette (incubator) and kept away from anything that will expose them to infections.

Using petrolatum-based creams have also helped keep their skin supple, soft and hydrated.

For older children who experience the formation of large scales on their skin, treatments that promote thinning and peeling of the outermost layer of the skin cells (stratum corneum) is often advised.

Such treatment may include taking long baths, using lubricants and keratolytic agents like urea preparations and alpha-hydroxy acid. Use of topical or oral retinoids might also help those who their skin is extremely affected.

Lamellar ichthyosis life expectancy

Many would wonder "what is the life expectancy of individuals with lamellar ichthyosis?" Do these children with this rare condition survive?

Babies born with the skin condition, lamellar ichthyosis experience symptoms like drying, cracking and scaling of skin but they do live to adulthood and have normal life expectancy, and live productive lives

The fact is that lamellar ichthyosis is often stable over a lifetime with occasional periods of exacerbation.

The condition also causes impairment to growth due to defective skin permeability barrier. But, lamellar ichthyosis is generally not life-threatening, and life expectancy is normal.

People wit ichthyosis live relatively normal, productive lives. Before now, babies born with the most severe form of ichthyosis known as Harlequin ichthyosis survived just about the first few days of life.

But, with recent advancements in medicine and neonatal care, harlequin infants now survive and live quite productive and fulfilling lives. Harlequin ichthyosis life expectancy can now be said to be normal.

Remember:

Lamellar ichthyosis skin condition is genetic and it is not contagious.

Is lamellar ichthyosis painful?

Because lamellar ichthyosis usually presents with skin disfiguration, people often have the notion that it must be painful.

In lamellar ichthyosis, there is often exfoliation of skin in clumps or plates. The scaling skin often leaves out brownish or reddish skin underneath, but the lamellar ichthyosis disorder is usually not painful.

Lamellar ichthyosis pictures

Lamellar ichthyosis belongs to a family of genetic skin disorders called 'ichthysosis' which is characterised by cracked, dry and scaling skin.

Check out some more lamellar ichthyosis pictures below. People with this condition mustn't be discriminated.

Their conditions are not as a result of bad sunburn or poor bathing habits, and they are pretty much humans just like you and me.

A collodian baby born with the collodion membrane (a clear, waxy and shiny skin layer)

After about 2 weeks, a baby born with lamellar ichthyosis disorder starts shedding the collodion membrane to reveal a red scaly skin underneath

Picture of a child with lamellar ichthyosis (typically experiences scaling all over the body, inability to sweat, abnormal finger and toenails)

Lamellar ichthyosis can cause changes to the eyes as well as excessive hair loss

Share With Friends